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©2013 UpToDate ® Print Email Test characteristics of anti-saccaromyces cervisiae antibodies (ASCA) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) in the diagnosis of inflammatory bowel disease (IBD) Antibody Sensitivity, percent Specificity, percent PPV, percent Sensitivity, specificity, and positive predictive value (PPV) in patients with IBD compared to non-IBD controls ASCA + 60 91 88 pANCA + 50 95 69 ASCA +/pANCA - 56 94 91 pANCA +/ASCA - 44 97 78 Sensitivity, specificity, and positive predictive value in differentiating ulcerative colitis (UC) from Crohn's disease (CD) in patients with IBD* ASCA +/CD + 60 86 92 pANCA +/UC + 50 94 76 ASCA +/pANCA -/CD + 56 92 95 pANCA +/ASCA -/UC + 44 98 88 * Where CD + or UC +, the control group for comparison is the other type of IBD. Data from: Peeters M, Joosens S, Vermeire S, et al. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol 2001; 96:730.