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©2013 UpToDate ® Print Email Changes in IgE and IgG resulting from subcutaneous allergen immunotherapy Profile of a typical patient illustrating the dose regimens for immunotherapy and the IgE and IgG antibody responses. Plotted are the relationships between time expressed in days, individual and cumulative doses of RW pollen extract expressed in nanograms of antigen E (AgE), and serum levels of RW-IgE, RW-IgG, and total IgE. A) RW-IgE, RW IgG, total IgE data. LL, large local reaction. B) Progressive cumulative dose (line) over respective single doses (bars) over time in days. Reproduced from: Creticos, PS, Van Metre, TE, Mardiney, MR, et al. Dose response of IgE and IgG antibodies during ragweed immunotherapy. J Allergy Clin Immunol 1984; 73:94. Illustration used with the permission of Elsevier Inc. All rights reserved.