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©2013 UpToDate ® Print Email In vivo screening protocol to detect the presence of aberrant adrenal hormone receptors in adrenal Cushing's syndrome Time, min Day 1 Day 2 Day 3 -60 Fasting-supine Fasting-supine Fasting-supine -15 * * * 0 Upright * GnRH 100 microgram IV * Glucagon 1 mg IV * +30 Upright * * * +60 Upright * * * +90 Upright * * * +120 Upright * * * +150 Supine * (Meal) +180 Mixed meal * Vasopressin 10 IU IM * +210 * * +240 * * +270 * * * +300 * TRH 200 microgram IV * * +330 * +360 ACTH 1-24 250 mircogram IV * * Metoclopramide 10 mg orally * +390 * * * +420 * * * +450 * * +480 * * *: Blood samples for determination of cortisol, ACTH, other hormones, and vital signs. Reproduced with permission from: Lacroix A, Mircescu, Hamet P. Clinical evaluation of the presence of abnormal hormone receptors in adrenal Cushing's syndrome. The Endocrinologist 1999; 9:9. Copyright © 1999 Lippincott Williams & Wilkins.