Browse the corpus

Gels: 0.05%, 0.1% Pregnancy category X; local skin irritation, dryness, and flaking; sun sensitivity Topical antimicrobials Benzoyl peroxide Twice daily Multiple 2.5 to 10% gels, lotions, creams, pads, masks, cleansers Local skin irritation; may bleach hair or clothing Clindamycin Twice daily Once daily (foam) 1% gel, lotion, pledget, solution, foam Rare risk of pseudomembranous colitis Erythromycin Twice daily 2% gel, solution, pledget Dapsone Twice daily 5% gel Sulfacetamide Twice daily 10% lotion, wash, suspension, pad plus 10% urea Topical combination products Benzoyl peroxide 5 percent/ Clindamycin 1 percent Twice daily Gel Local skin irritation; may bleach hair or clothing Benzoyl peroxide 2.5 percent/ Clindamycin 1.2 percent Once daily Gel Locak skin irritation; may bleach hair or clothing Benzoyl peroxide 5 percent/ Erythromycin 3 percent Twice daily Gel Local skin irritation; may bleach hair or clothing Clindamycin 1.2 percent/ Tretinoin 0.025 percent Once daily, at bedtime Gel Local skin irritation Benzoyl peroxide 2.5 percent/ Adapalene 0.1 percent Once daily Gel Local skin irritation; may bleach hair or clothing Azelaic acid Twice daily 20% cream, 15% gel Local skin irritation Oral antibiotics* Tetracycline 500 mg twice daily Photosensitivity, gastrointestinal distress; contraindicated in pregnancy and young children Doxycycline 50 to 100 mg twice daily or 150 mg once daily Photosensitivity, gastrointestinal distress; contraindicated in pregnancy and young children Minocycline 50 to 100 mg twice daily or 1 mg/kd/day of extended release formulation (round to nearest available strength: 45, 65, 90 or 135 mg tablets) Dizziness, drug-induced lupus, skin discoloration; contraindicated in pregnancy and young children Erythromycin 500 mg twice daily (base) Gastrointestinal distress Trimethoprim-sulfamethoxazole 160 mg/800 mg once to twice daily Stevens-Johnson syndrome, toxic epidermal necrolysis Azithromycin Intermittent dosing due to long drug half-life; optimum regimen unknown Gastrointestinal distress Hormonal agents* Combination oral contraceptives (estrogen/progestin) Once daily Nausea, breast tenderness, weight gain, thromboembolic events; see topic entitled "Risks and side-effects associated with estrogen-progestin contraceptives" Spironolactone 25 to 200 mg/day in one or two equally divided doses; doses of 50 to 100 mg/day may be as effective as higher doses and reduce side effects

Combination oral contraceptives (estrogen/progestin) Once daily Nausea, breast tenderness, weight gain, thromboembolic events; see topic entitled "Risks and side-effects associated with estrogen-progestin contraceptives" Spironolactone 25 to 200 mg/day in one or two equally divided doses; doses of 50 to 100 mg/day may be as effective as higher doses and reduce side effects Contraindicated in pregnancy; menstrual irregularity, breast tenderness, minor gastrointestinal symptoms, orthostatic hypotension, hyperkalemia, dizziness, headaches, fatigue Oral retinoid Oral isotretinoin 0.5 mg/kg/day, increasing to 1 mg/kg/day in one or two equally divided doses; total dose 120 to 150 mg/kg over 20 weeks Teratogenicity (absolutely contraindicated in pregnancy), mucocutaneous effects, hypertriglyceridemia, others; see topic entitled "Oral isotretinoin therapy for acne vulgaris" %: percent. * Usual oral dose for adult or adolescent.