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©2013 UpToDate ® Print Email Differential diagnosis of acquired pure red cell aplasia in children Acquired Primary Autoimmune Idiopathic* Transient erythroblastopenia of childhood (TEC) Secondary Thymoma and malignancy Thymoma Lymphoid malignancies Paraneoplastic syndrome with solid tumors Collagen vascular disorders Systemic lupus erythematosus (SLE) Juvenile idiopathic arthritis (JIA) Rheumatoid arthritis Infections* Parvovirus* Hepatitis A, B, C Epstein-Barr virus (EBV) Human immunodeficiency virus (HIV) Human herpesvirus 6 (HHV6) Echovirus 11 Autoantibodies Pregnancy Malnutrition/protein deficiency Drugs Drugs probably associated Phenytoin Azathioprine Isoniazid Chlorpropamide Valproic acid Chloramphenicol and thiamphenicol Sulfonamides Procainamide Drugs possibly associated Allopurinol Carbamazepine Chloroquine Dapsone Fenoprofen Penicillamine Gold * Common causes of acquired pure red cell aplasia in the pediatric population. Data from: Alter BP, Young NS. The Bone Marrow Failure Syndromes. In: Nathan and Oski's Hematology of Infancy and Childhood, Nathan DG, Orkin SH (Eds), W.B. Saunders Company, 1998, p.237. Thompson DF, Gales MA, Pharmacotherapy 1996; 16:1002. Lin YW, Okazaki S, Hamahata K, et al, Am J Hematol 1999; 61:209.