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©2013 UpToDate ® Print Email Patients with acquired lipodystrophies (A) Lipodystrophy in a man with human immunodeficiency virus who received antiretroviral therapy containing a protease inhibitor for six years. Note the loss of fat from the face, arms, and legs, increased abdominal fat, and buffalo hump. (B) Acquired partial lipodystrophy in a woman with Barraquer-Simons' syndrome. The loss of subcutaneous fat from the face, neck, arms, thorax, and upper abdomen began in adolescence. Note the excess subcutaneous fat in the legs. (C) Acquired generalized lipodystrophy. The generalized loss of subcutaneous adipose tissue began in adolescence. Complications include severe insulin resistance, hyperinsulinemia, hypertriglyceridemia, and low serum high-density lipoprotein cholesterol concentrations.