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contentuptodate· Content· item f4_52_4928

©2013 UpToDate ® Print Email Action of PAs PAs compete with agonist for binding to PR and promote the activation steps of dimerization and binding to specific PREs of target DNA. However PAs induce an altered conformation in PR that is transcriptionally inactive, resulting in a nonproductive interaction of receptor with DNA. This is caused by PR recruitment of corepressors (NCoR and SMRT) instead of coactivators. Leonhardt, SA, Edwards, DP. Exp Biol Med 2002; 227:969. Copyright © 2005 Society for Experimental Biology and Medicine.