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contentuptodate· Content· item f14_36_14915

©2013 UpToDate ® Print Email Activation of the TPO receptor The TPO receptor has been proposed to exist as an inactive preformed dimer (left) with a proximal (HRD-1) and distal (HRD-2) hematopoietic receptor domain (HRD). Upon binding of thrombopoietin to the distal HRD-2, the receptor (right) conformation changes and a number of signal transduction pathways are activated that increase platelet production. Illustration by Paulette Dennis. This research was originally published in Blood. Kuter, DJ. New thrombopoietic growth factors. Blood 2007; 109:4607. Copyright © 2007 American Society of Hematology.