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©2013 UpToDate ® Print Email Activation of G proteins Upon binding of hormone to the receptor, a change occurs in the structure of the hormone-receptor complex such that a G-protein is recruited to the membrane and activated. G-proteins are composed of three subunits (alpha, beta and gamma). G-protein stimulation then initiates a variety of cellular processes. Courtesy of Michael A Shetzline, MD, PhD and Rodger A Liddle, MD.