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©2013 UpToDate ® Print Email Acute NSAID toxicity: Rapid overview To obtain emergent consultation with a medical toxicologist, call the United States Poison Control Network at 1-800-222-1222, or access the World Health Organization's list of international poison centers ( www.who.int/gho/phe/chemical_safety/poisons_centres/en/index.html ). History Ask specifically about acetaminophen and aspirin ingestion Ascertain type of NSAID, amount ingested, when ingested Clinical and laboratory features NSAIDS are usually well tolerated in overdose, with minimal toxicity Severe acute overdose may result in alterations in mental status, seizure, metabolic acidosis, or renal insufficiency Anaphylaxis may occur Diagnostic evaluation Basic electrolytes to assess concentrations and acid-base status; baseline renal function (indicated only in moderate to severe overdose) Acetaminophen and salicylate concentrations to rule out concurrent pain medication ingestion Fingerstick glucose to rule out hypoglycemia as an etiology of any alteration in mental status Electrocardiogram to assess for toxin-induced prolongation of the QRS or QTc intervals Arterial blood gas in severe overdose or altered mental status Pregnancy test for women of child-bearing age Treatment Secure airway, breathing, and circulation (rarely an issue in pure NSAID poisoning) Give gastrointestinal decontamination: activated charcoal, 1 g/kg There is no antidote for NSAID poisoning; supportive care will usually suffice