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©2013 UpToDate ® Print Email Acute liver failure (high power, Masson trichrome stain) The only cells visible are macrophages, many filled with yellow-brown pigment granules. Lipofuscin (often called "wear and tear pigment") is composed of lipid-containing residues of lysosomal digestion. Its presence in high concentration in macrophages suggests extensive liver cell necrosis. The blue structures are all that remains of sinusoidal membranes that normally surround the hepatic plates. Courtesy of Marshall M. Kaplan, MD.