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Centers for Disease Control and Prevention, “Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-infected Adults and Adolescents: Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America,” MMWR Recomm Rep , 2009, 58(4):1-207. [PubMed 19357635 ] Centers for Disease Control and Prevention (CDC), "Sexually Transmitted Diseases Treatment Guidelines, 2010," MMWR Recomm Rep , 2010, 59(RR-12):1-110. [PubMed 21160459 ] Cernik C, Gallina K, and Brodell RT, “The Treatment of Herpes Simplex Infections: An Evidence-Based Review,” Arch Int Med , 2008, 168(11):1137-44. [PubMed 18541820 ] Dunkle LM, Arvin AM, Whitley RJ, et al, “A Controlled Trial of Acyclovir for Chickenpox in Normal Children,” N Engl J Med , 1991, 325(22):1539-44. [PubMed 1944438 ] Eck P, Silver SM, and Clark EC, “Acute Renal Failure and Coma After a High Dose of Oral Acyclovir,” N Engl J Med , 1991, 325(16):1178-9. [PubMed 1891032 ] Eisen D, Essell J, Broun ER, et al, “Clinical Utility of Oral Valacyclovir Compared With Oral Acyclovir for the Prevention of Herpes Simplex Virus Mucositis Following Autologous Bone Marrow Transplantation or Stem Cell Rescue Therapy,” Bone Marrow Transplant , 2003, 31(1):51-5. [PubMed 12621507 ] Englund JA, Fletcher CV, and Balfour HH Jr, “Acyclovir Therapy in Neonates,” J Pediatr , 1991, 119(1 Pt 1):129-35. [PubMed 2066845 ] Gartner LM, Morton J, Lawrence RA, et al, "Breastfeeding and the Use of Human Milk," Pediatrics , 2005, 115(2):496-506. [PubMed 15687461 ] Heintz BH, Matzke GR, Dager WE, “Antimicrobial Dosing Concepts and Recommendations for Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy or Intermittent Hemodialysis,” Pharmacotherapy , 2009, 29(5):562-77. [PubMed 19397464 ] Henderson GI, Hu ZQ, Johnson RF, et al, "Acyclovir Transport by the Human Placenta," J Lab Clin Med , 1992, 120(6):885-92. [PubMed 1453110 ] Leflore S, Anderson PL, and Fletcher CV. “A Risk-Benefit Evaluation of Aciclovir for the Treatment and Prophylaxis of Herpes Simplex Virus Infections,” Drug Safety , 2000, 23(2):131-42. [PubMed 10945375 ] National Comprehensive Cancer Network (NCCN), “Clinical Practice Guidelines in Oncology™: Prevention and Treatment of Cancer-Related Infections,” Version 1.2008. Available at file://www.nccn.org/professionals/physician_gls/PDF/infections.pdf

Leflore S, Anderson PL, and Fletcher CV. “A Risk-Benefit Evaluation of Aciclovir for the Treatment and Prophylaxis of Herpes Simplex Virus Infections,” Drug Safety , 2000, 23(2):131-42. [PubMed 10945375 ] National Comprehensive Cancer Network (NCCN), “Clinical Practice Guidelines in Oncology™: Prevention and Treatment of Cancer-Related Infections,” Version 1.2008. Available at file://www.nccn.org/professionals/physician_gls/PDF/infections.pdf Novelli VM, Marshall WC, Yeo J, et al, “High-Dose Oral Acyclovir for Children at Risk of Disseminated Herpesvirus Infections,” J Infect Dis , 1985, 151(2):372. [PubMed 2981940 ] Raborn GW, Martel AY, Grace MG, et al, “Oral Acyclovir in Prevention of Herpes Labialis. A Randomized, Double-Blind, Multi-Centered Clinical Trial,” Oral Surg Oral Med Oral Pathol Oral Radiol Endod , 1998, 85(1):55-9. [PubMed 9474615 ] Rayani SA, Nimmo CJ, Frighetto L, et al, “Implementation and Evaluation of a Standardized Herpes Simplex Virus Prophylaxis Protocol on a Leukemia/Bone Marrow Transplant Unit,” Ann Pharmacother , 1994, 28(7-8):852-6. [PubMed 7949499 ] Rooney JF, Straus SE, Mannix ML, et al, “Oral Acyclovir to Suppress Frequently Recurrent Herpes Labialis. A Double-Blind, Placebo-Controlled Trial,” Ann Intern Med , 1993, 118(4):268-72. [PubMed 8380540 ] Spruance SL, Hamill ML, Hoge WS, et al, “Acyclovir Prevents Reactivation of Herpes Simplex Labialis in Skiers,” JAMA , 1988, 260(11):1597-9. [PubMed 3411740 ] Spruance SL, Stewart JCB, Rowe NH, et al, “Treatment of Recurrent Herpes Simplex Labialis With Oral Acyclovir,” J Infect Dis , 1990, 161(2):185-90. [PubMed 2153735 ] Trotman RL, Williamson JC, Shoemaker DM, et al, "Antibiotic Dosing in Critically Ill Adult Patients Receiving Continuous Renal Replacement Therapy," Clin Infect Dis , 2005, 41(8):1159-66. [PubMed 16163635 ] Wade JC, Newton B, Flournoy N, et al, “Oral Acyclovir for Prevention of Herpes Simplex Virus Reactivation After Marrow Transplantation,” Ann Intern Med , 1984, 100(6):823-8. [PubMed 6326632 ] Wood MJ, Johnson RW, McKendrick MW, et al, “A Randomized Trial of Acyclovir for 7 Days or 21 Days With and Without Prednisolone for Treatment of Acute Herpes Zoster,” N Engl J Med , 1994, 330(13):896-900. [PubMed 8114860 ] Topic 8628 Version 50.0

Wade JC, Newton B, Flournoy N, et al, “Oral Acyclovir for Prevention of Herpes Simplex Virus Reactivation After Marrow Transplantation,” Ann Intern Med , 1984, 100(6):823-8. [PubMed 6326632 ] Wood MJ, Johnson RW, McKendrick MW, et al, “A Randomized Trial of Acyclovir for 7 Days or 21 Days With and Without Prednisolone for Treatment of Acute Herpes Zoster,” N Engl J Med , 1994, 330(13):896-900. [PubMed 8114860 ] Topic 8628 Version 50.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.4 - C21.36 Licensed to: Southeast Alabama Med Ctr | Support Tag: [1005-89.218.100.194-EFEE8658EB-S244013.14]