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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Major adverse effects of methotrexate* Bone marrow toxicity Neutropenia (most common, usually reversible) Thrombocytopenia (dose related, usually reversible) Anemia (rare) Hepatic toxicity Cirrhosis & fibrosis Pulmonary toxicity Opportunistic infections PCP, CMV, Herpes zoster, fungal, mycobacterial, etc Noninfectious conditions Hypersensitivity pneumonitis Organizing pneumonia (previously called bronchiolitis obliterans with organizing pneumonia or BOOP) Acute lung injury (noncardiogenic pulmonary edema) Pulmonary fibrosis Asthma/hyperreactive airways disease Pleuritis and/or pleural effusion Miscellaneous Oligospermia Teratogenicity Malignancy PCP: Pneumocystis pneumonia; CMV: cytomegalovirus. * Major adverse effects are defined as potentially life-threatening (incidence <1 percent) or requiring withdrawal of treatment (incidence 3 to 15 percent).