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©2013 UpToDate ® Print Email Age-related bone loss The mg of hydroxyapatite lost with age was measured using high resolution peripheral CT of the distal radius in a cross-sectional study of 122 white women with a mean age of 62.8 (range 27 to 98) years. Please note that most bone lost after the age of 65 was cortical. Cortical porosity was measured using scanning electron microscopy of post-mortem specimens of femora from 24 women with a mean age of 69 (range 29 to 99) years and is depicted in a schematic fashion. * p<0.0001. Reproduced from: Zebaze RM, Ghasem-Zadeh A, Bohte A, et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: A cross-sectional study. Lancet 2010; 375:1729. Illustration used with the permission of Elsevier Inc. All rights reserved.