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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.

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contentuptodate· Content· item f31_40_32395

©2013 UpToDate ® Print Email Age-related changes in the adaptive immune system Cell type Age-related decrease Age-related increase No change Thymic precursors Thymus size Number of thymic precursors T lymphocytes Number of naïve T cells Diversity of T cell repertoire Proliferative capacity Signaling intensity Regulatory T cell function B lymphocytes B cells precursors in the bone marrow (pre-B cells) Peripheral B cell numbers B cell repertoire Antibody response Opsonizing capacity of immunoglobulins Autoreactive serum antibodies Immunoglobulin levels (may increase)