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©2013 UpToDate ® Print Email Agents responsible for reactive airways dysfunction syndrome Agent Study Evidence References Acetic acid epidemiologic H, S, BR Am Rev Respir Dis 1991; 144:1058 case report H, S, P Br J Ind Med 1989; 4 6:67 Sulfuric acid case report H, S, BR Chest 1988; 94:476 Hydrochloridic acid case report H, S Chest 1988; 94:476 case report H, S, BR Chest 1985; 88:376 Chest 1990; 98:928 Various acids case report H, S, BR, P Chest 1985; 88:376 JOM 1994; 36:623 Heated acid case report H, S, BR, P Chest 1985; 88:376 Ammonia case report H, S Mayo Clin Proc 1983; 58:389 Thorax 1992; 47:755 Bleaching agent case report H, S, BR Chest 1988; 94:476 epidemiologic H Am J Ind Med 2003; 43:532 Bromochlorodifluoro- methane case report H, S, BR Occup Env Med 2004; 61:712 Bromotrifluoromethane case report H, S Eur Respir J 1999; 13:1192 Chlorine epidemiologic H, S, BR Occup Env Med 1994; 61:712 epidemiologic H Env Res 2002; 88:89 clinical H, S, BR, P Toxicol Industrial Health 1993; 9:439 Chloropicrin experimental P Toxicol Appl Pharm 1984; 74:417 Cleaning agents case report H, S Chest 1976; 69:372 Diesel exhaust case report H, S, BR Chest 1985; 88:376 J Occup Med 1993; 35:149 Diethylaminoethanol epidemiologic H, S J Occup Med 1994; 36:623 Epichlorohydrin experimental P Toxicol Appl Pharm 1984; 74:417 Ethylene oxide case report H, S, BR, P Br J Ind Med 1992; 49:523 Fire/smoke case report H, S, BR Chest 1988; 94:476 epidemiologic, case report H, S, BR, P Occup Med 1993; 8:431 case report H, S Chest 1985; 88:376 J Occup Med 1991; 33:458 epidemiologic H, S, BR Am J Respir Crit Care Med 2003; 168:54 Formaldehyde case report H, S, BR Allergy 2004; 59:15 H: clinical history; S: spirometry; BR: bronchial responsiveness; P: pathology. Agents responsible for reactive airways dysfunction syndrome, continued Agent Study Evidence References Floor sealer case report H, S, BR Chest 1988; 94:476 Floor polish epidemiologic H Int Arch Ocup Environ Health 2000; 73:498 Fluorocarbon case report H, S, BR Eur Respir J 1999; 13:1192 Formol case report H, S Lancet 1975; 2:603 Freon (degradation) case report H, S, Br, P Scand J Work Environ Health 2003; 29:71 Cleaning mist (perchloroethylene) case report H, S, BR Chest 1988; 94:476 Hydrazine case report H, S, BR Chest 1988; 94:476 Iodine compounds case report H, S, BR, P Ind Health 2009; 47:681 Isocyanates case report H, S, BR Scand J Work Environ Health 1981; 7:310 case report H, S, BR, P Allergy 1996; 51:262 experimental S Toxicol App Pharmacol 1987; 89:332 case report H, S Br J Ind Med 1990; 47:239 case report H, S, BR Am J Ind Med 2003; 44:325 case report H, S, BR Chest 1989; 96:297 case report H, S, BR Am J Ind Med 2003; 44:325 Metal remover case report H, S, BR Chest 1988; 94:476 Oxyde (calcium) case report H, S, BR Chest 1989; 96:297 Paints (heated) case report

Allergy 1996; 51:262 experimental S Toxicol App Pharmacol 1987; 89:332 case report H, S Br J Ind Med 1990; 47:239 case report H, S, BR Am J Ind Med 2003; 44:325 case report H, S, BR Chest 1989; 96:297 case report H, S, BR Am J Ind Med 2003; 44:325 Metal remover case report H, S, BR Chest 1988; 94:476 Oxyde (calcium) case report H, S, BR Chest 1989; 96:297 Paints (heated) case report H, S, BR Chest 1989; 96:297 Pesticides epidemiologic H, S Am J Ind Med 2003; 43:447 Phthalic anhyride case report H, S, BR Rev Pneumol Clin 1993; 49:247 Spray paint case report H, S, BR, P Chest 1989; 96:297 Chest 1985; 88:376 Sulfur dioxide case report H, S, BR, P Am Rev Respir Dis 1979; 119:555 Chest 1990; 98:928 case report H, S, BR Am Rev Respir Dis 1983; 128:890 Thorax 1992; 47:755 case report H, P Arch Int Med 1919; 24:678 Gas (chlorine, mustard, phosgene, etc) case report H, P Br Med J 1915; 165 Teargas case report H, S, BR Rev Mal Respir 1999; 16:558 H: clinical history; S: spirometry; BR: bronchial responsiveness; P: pathology.

©2013 UpToDate ® Print Email Agents responsible for reactive airways dysfunction syndrome Agent Study Evidence References Acetic acid epidemiologic H, S, BR Am Rev Respir Dis 1991; 144:1058 case report H, S, P Br J Ind Med 1989; 4 6:67 Sulfuric acid case report H, S, BR Chest 1988; 94:476 Hydrochloridic acid case report H, S Chest 1988; 94:476 case report H, S, BR Chest 1985; 88:376 Chest 1990; 98:928 Various acids case report H, S, BR, P Chest 1985; 88:376 JOM 1994; 36:623 Heated acid case report H, S, BR, P Chest 1985; 88:376 Ammonia case report H, S Mayo Clin Proc 1983; 58:389 Thorax 1992; 47:755 Bleaching agent case report H, S, BR Chest 1988; 94:476 epidemiologic H Am J Ind Med 2003; 43:532 Bromochlorodifluoro- methane case report H, S, BR Occup Env Med 2004; 61:712 Bromotrifluoromethane case report H, S Eur Respir J 1999; 13:1192 Chlorine epidemiologic H, S, BR Occup Env Med 1994; 61:712 epidemiologic H Env Res 2002; 88:89 clinical H, S, BR, P Toxicol Industrial Health 1993; 9:439 Chloropicrin experimental P Toxicol Appl Pharm 1984; 74:417 Cleaning agents case report H, S Chest 1976; 69:372 Diesel exhaust case report H, S, BR Chest 1985; 88:376 J Occup Med 1993; 35:149 Diethylaminoethanol epidemiologic H, S J Occup Med 1994; 36:623 Epichlorohydrin experimental P Toxicol Appl Pharm 1984; 74:417 Ethylene oxide case report H, S, BR, P Br J Ind Med 1992; 49:523 Fire/smoke case report H, S, BR Chest 1988; 94:476 epidemiologic, case report H, S, BR, P Occup Med 1993; 8:431 case report H, S Chest 1985; 88:376 J Occup Med 1991; 33:458 epidemiologic H, S, BR Am J Respir Crit Care Med 2003; 168:54 Formaldehyde case report H, S, BR Allergy 2004; 59:15 H: clinical history; S: spirometry; BR: bronchial responsiveness; P: pathology.