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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Algorithm for the diagnosis of antibody-mediated rejection of renal allograft with renal dysfunction Algorithm proposed by the Antibody Working Group for the diagnosis of antibody-mediated rejection (AMR), if allograft dysfunction is present. A high risk setting (husband to wife or child to mother donor-recipient pairs, history of a sensitizing event (such as pregnancy, tranfusion, transplant), and knowledge of HLA-specific antibody (either present or historic) determines the predictive value of the various histologic and laboratory features, which are the major diagnostic modifiers. The presence of donor-specific antibody (DSA) is not essential for the diagnosis of AMR in a high-risk situation but can be diagnostic in the presence of C4d or histologic features of AMR even in a low-risk clinical setting. Adapted from Montgomery, RA, et al. Transplantation 2004; 78:181.