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©2013 UpToDate ® Print Email Approach to the septic-appearing infant ABC: airway, breathing, circulation; IV: intravenous catheter; PE: physical examination; CSF: cerebrospinal fluid; CXR: chest radiograph; HSV: herpes simplex virus; SVT: supraventricular tachycardia; CAH: congenital adrenal hyperplasia. * Cultures of blood and urine, CBC, enhanced UA, electrolytes, glucose. Consider lumbar puncture (for patients able to tolerate procedure), CXR, and other studies (such as bilirubin or arterial blood gas) as indicated by history and physical examination. • Patients who cannot tolerate lumber puncture (LP) should have a blood culture and receive antibiotics. LP should be performed once patient's condition is stabilized.