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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Benefit of alosetron in diarrhea-predominant IBS Results of a controlled trial of 647 women with irritable bowel syndrome (IBS) that was either diarrhea-predominant or had alternating diarrhea and constipation. The women were randomly assigned to alosetron (1 mg twice daily) or placebo for 12 weeks. A significantly greater proportion of women treated with alosetron (41 verses 29 percent with placebo) described adequate relief for all three months of therapy. This difference disappeared with cessation of therapy. Data from Camilleri, M, Northcutt, AR, Kong, S, et al. Lancet 2000; 355:1035.