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©2013 UpToDate ® Print Email Conditions and therapies that can affect the physiology of the oral cavity in children Condition Physiologic modification of the oral cavity Dental management Asthma Medications implicated in increased caries rate Modification of sucrose-containing-medication intake Platelet disorders Oral mucosal and gingival bleeding Maintenance of oral hygiene Hemophilia Oral and mucosal bleeding Maintenance of oral hygiene Cancer and its treatment Oral bleeding; oral infection; impaired healing Treat according to protocols that account for impaired hematopoietic system Seizure disorders Decreased salivary flow; gingival overgrowth (diphenylhydantoin) Maintenance of oral hygiene; surgical management of gingival conditions Organ transplantation Gingival overgrowth secondary to cyclosporine and calcium channel blockers Maintenance of oral hygiene; surgical management of gingival conditions Behavioral, emotional, and psychiatric disorders treated with CNS medications Decreased salivary flow Maintenance of oral hygiene; use of topical fluoride mouth rinses Chronic renal failure Uremic bone disease; impaired healing Maintenance of oral hygiene Juvenile idiopathic arthritis Increased caries from sucrose-containing medications Maintenance of oral hygiene; use of topical fluoride mouth rinses Bulimia Erosion of teeth Restoration of teeth; use of topical fluorides Gastrostomy Increased calculus formation Maintenance of oral hygiene; increased frequency of calculus removal CNS: central nervous system. Reproduced with permission from: Casamassimo PS. Pediatr Clin North Am 2000; 47:1149. Copyright © 2000 W.B. Saunders Co.