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Trientine: Magnesium Salts may decrease the serum concentration of Trientine. Trientine may decrease the serum concentration of Magnesium Salts. Risk D: Consider therapy modification Ursodiol: Aluminum Hydroxide may decrease the serum concentration of Ursodiol. Management: Consider administration of ursodiol 2 hours before or 6 hours after aluminum-containing antacid products to prevent adsorption in the gastrointestinal tract. Risk D: Consider therapy modification Vismodegib: Antacids may decrease the serum concentration of Vismodegib. Management: Carefully consider the need for any medication that increases the pH of the upper GI tract (PPIs, H2RAs, antacids), as these could significantly reduce vismodegib systemic exposure. Vismodegib dose increases are unlikely to compensate for this effect. Risk D: Consider therapy modification Vitamin D Analogs: May increase the serum concentration of Aluminum Hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Risk X: Avoid combination Pregnancy Implications See individual agents. Breast-Feeding Considerations See individual agents. Dietary Considerations Should be taken 1-3 hours after meals. Some products may contain potassium. Pricing: U.S. (Medi-Span®)

Suspension (Mylanta Oral) 200-200-20 mg/5 mL (355 mL): $4.90 International Brand Names Acibiogel (CO); Acitral (ID); Dexanta (ID); Eviline (HK); Gelusil Plus (TW); Gelusil-S (ZA); Hydrosil (HK); Maalox Plus (CN, GR, MY); Mylanta (AU, NZ, SG) Use of UpToDate is subject to the Subscription and License Agreement . Topic 8616 Version 42.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.6- C21.56 Licensed to: AsanBook Dig. Med. Lib. | Support Tag: [0504-125.39.66.147-8BB6C55152-S244013.14]