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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Amino acid composition of native GnRH and GnRH agonist analogues Amino acid position 1 2 3 4 5 6 7 8 9 10 GnRH Analogue pGlu His Trp Ser Tyr Gly Leu Arg Pro Gly-NH2 Leuprolide pGlu His Trp Ser Tyr D-Leu6 Leu Arg N-ethyl Pro Nafarelin pGlu His Trp Ser Tyr D-Nal(2)6 Leu Arg Pro Gly-NH2 Goserelin pGlu His Trp Ser Tyr D-Ser(tBu)6 Leu Arg Pro Aza-Gly-NH10 Buserelin pGlu His Trp Ser Tyr D-Ser(tBu)6 Leu Arg Pro Histrelin pGlu His Trp Ser Tyr Imbzl-D-His6 Leu Arg Pro All of the agonists have amino acid changes at positions 6 and most have changes at position 10. Courtesy of Robert L Barbieri, MD.