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©2013 UpToDate ® Print Email Once-daily dosing nomogram for aminoglycosides Nomogram showing the relationship between serum gentamicin or tobramycin concentrations and time beginning at six hours after a single dose of 7 mg/kg. The interval for drug administration varied with estimated creatinine clearance (Ccr): every 24 hours at a Ccr ≥60 mL/min; every 36 hours at a Ccr of 40 to 59 mL/min; and every 48 hours at a Ccr of 20 to 39 mL/min. Reproduced with permission from: Nicolau, D, Quintiliani, R, Nightingale, CH. Once-daily aminoglycosides. Conn Med 1992; 56:561. Copyright © 1992 Connecticut State Medical Society.