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©2013 UpToDate ® Print Email Amiodarone toxicity Amiodarone lung biopsy photomicrograph shows diffuse alveolar damage in a patient with amiodarone toxicity. Alveolar spaces contain histiocytes with finely vacuolated cytoplasm (arrow). Chronic interstitial pneumonia with fibrosis and organizing pneumonia have also been described in patients with amiodarone toxicity. Courtesy of Jeffrey L Myers, MD. Normal lung High power photomicrograph shows alveoli containing capillaries within a narrow interstitium. The alveoli are lined with thin, elongated type I pneumoctes (red arrow) and smaller numbers of cuboidal type II pneumocytes (green arrow). Courtesy of Steven E Weinberger, MD.