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©2013 UpToDate ® Print Email Protein precursor of amyloid deposits-II Protein class Precursor protein (abbreviation) Amyloid type Clinical type Transport protein Transthyretin (TTR; prealbumin) ATTR Hereditary neuropathic and/or cardiopathic amyloids; vitreous amyloidosis; leptomeningeal or renal amyloid in some kindreds; senile systemic amyloidosis [1] Cerebrovascular/ neurdegeneration Amyloid precursor protein (APP) ABeta Hereditary and sporadic Alzheimer disease; congophilic cerebral angiopathy [2,3] Prion protein (PRP) APrPsc Hereditary and sporadic spongiform encephalopathies [4] BRI gene product ABri/ADan Hereditary dementias (British and Danish types) [5] Cystatin C (Cys - C) ACys Hereditary cerebrovascular hemorrhage with amyloidosis (Icelandic type) [6] Coagulation protein Fibrinogen alpha chain AFib Hereditary nephropathic amyloidosis [7] Enzyme Lysozome ALys Hereditary nephropathic amyloidosis; may have marked hepatic, splenic and gastrointestinal amyloid deposits [7] Other Keratoepithelin AKer Various familial corneal dystrophies [8] Lactoferrin ALac Corneal amyloidosis associated with trichiasis Odontogenic ameloblast-associated protein AOaap Calcifying epithelial odontogenic tumors (CEOTs) Semenogelin 1 ASem1 Senile seminal vesicle amyloid Lactadherin AMed Senile aortic amyloid; media deposition Leukocyte chemotactic factor 2 ALect2 Amyloid nephropathy References: Connors LH, Lom A, Prokaeva T, et al. Amyloid 2003; 10:160 (TTR variants updated at file://medicine.bu.edu/amyloid/Amyloidl.htm). Selkoe DJ. Physiol Revs 2001; 81:741. Revesz T, Ghiso J, Lashley T, et al. J Neuropathol Exp Neurol 2003; 62:885. Prusiner SB. N Engl J Med 2001; 344:1516. Vidal R, Frangione B, Rostagno A, et al. Nature 1999; 399:776 and Gibson G, Gunasekera N, Lee M, et al. J Neurochem 2004; 88:281. Olafsson I, Grubb A. Amyloid 2000; 7:70. Hawkins PN. J Nephrol 2003; 16:443. Klintworth GK. Front Biosci 2003; 8:d687. Sipe JD, Benson MD, Buxbaum JN, et al. Amyloid 2010; 17:101.