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©2013 UpToDate ® Print Email Anaphylaxis mechanisms and triggers Anaphylaxis mechanisms and triggers: Anaphylaxis typically occurs through an IgE-dependent immunologic mechanism, most commonly triggered by foods, stinging insect venoms, or medications. * Trigger anaphylaxis by more than one mechanism. • NSAIDs: non-steroidal anti-inflammatory drugs. Δ HMW: high molecular weight. Reproduced with permission from: Simons FER, Ardusso LRF, Beatrice Bilo M, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. WAO Journal 2011; 4:13. Copyright © 2011 Lippincott Williams & Wilkins.