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©2013 UpToDate ® Print Email Central pathways of ADH release Diagram of the mammalian hypothalamus and pituitary gland showing pathways for the secretion of antidiuretic hormone (ADH). The hormone is formed in the supraoptic and paraventricular nuclei, transported in granules along their axons, and then secreted at three sites: the posterior pituitary gland, the portal capillaries of the median eminence, and the cerebrospinal fluid (CSF) of the third ventricle. Adapted from Zimmerman, EA, Robinson, AG, Kidney Int 1976; 10:12. Reprinted by permission from Kidney International.