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©2013 UpToDate ® Print Email Antibiotic selection for Legionella infection in adults Antimicrobial agent Dosing* Macrolides Azithromycin 1 g for the first dose, then 500 mg orally or intravenously• every 24 hr Clarithromycin 500 mg orally or intravenouslyΔ every 12 hr Quinolones Levofloxacin 750 mg orally or intravenously every 24 hr Ciprofloxacin 400 mg intravenously every 8 hr 750 mg orally every 12 hr Ofloxacin 400 mg orally or intravenously every 12 hr Moxifloxacin 200 mg orally every 24 hr Tetracyclines Doxycycline 100 mg orally or intravenously every 12 hr Minocycline 100 mg orally or intravenously every 12 hr Tetracycline 500 mg orally or intravenously every 6 hr Tigecycline 100 mg intravenously for the first dose, then 50 mg every 12 hours thereafter Other Trimethoprim-sulfamethoxazole 160 and 800 mg intravenously every 8 hr * Doses based on clinical experience and not on controlled trials. • Intravenous form not available in some countries.