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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Antibiotics for suspected shigellosis in developing settings Antibiotic Route Typical pediatric dose Comment(s) Preferred agents Ciprofloxacin Oral 30 mg/kg/day (divided twice daily) for 3 days Multi-dose therapy is preferred. Azithromycin Oral 15 mg/kg initial dose (day 1) 10 mg/kg/day (daily, day 2-5) Alternative agents Ceftriaxone IM/IV 50-100 mg/kg/day (divided four times daily) for 2-5 days Ceftriaxone is the preferred empiric therapy for severe infections and infections refractory to other therapies. Pivmecillinam PO 80 mg/kg/day (divided four times daily) for 5 days Resistance to amoxicillin, trimethoprim-sulfamethoxazole, and chloramphenicol (original first-line therapies) is too widespread to justify their empiric use for invasive diarrhea in developing countries. Modified from: World Health Organization. Guidelines for the control of shigellosis, incuding epidemics due to Shigella dysenteriae 1. World Health Organization, Geneva 2005.