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©2013 UpToDate ® Print Email Sensitivity and specificity of antibody tests for celiac disease in children Sensitivity, (percent) Specificity, (percent) Tissue transglutaminase; tTG (IgA, human) [1-3] 90 to 100 95 to 100 Anti-endomysial antibody (IgA) [1] 93 to 100 98 to 100 Antigliadin antibody IgA [1] 52 to 100 72 to 100 Antigliadin antibody IgG [1] 83 to 100 47 to 94 Deamidated gliadin peptide; DGP (IgA)*  [4] 80 to 91 91 to 95 Deamidated gliadin peptide; DGP (IgG)* [4] 88 to 95 86 to 98 * Sensitivity and specificity of DGP may be better in children younger than two years of age as compared with tTG or anti-endomysial antibodies. [5] References Hill, ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 2005; 128 (4 Suppl 1):S25 Basso, D, Guariso, G, Fasolo, M, et al. A new indirect chemiluminescent immunoassay to measure anti-tissue transglutaminase antibodies. J Pediatr Gastroenterol Nutr 2006; 43:613. Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther 2010; 31:73. Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol 2007; 5:1276. Mubarak A, Gmelig-Meyling FHJ, Wolters VM et al. Immunoglobulin G antibodies against deamidated-gliadin-peptides outperform anti-endomysium and tissue transglutaminase antibodies in children <2 years age. APMIS 2011; 119:894.