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©2013 UpToDate ® Print Email Chance of side effects with certain antidepressant medicines Medicine name* Chance that it will make you sleepy Chance that it will make it hard to sleep or make you jittery Chance that it will upset your stomach Chance that it will cause sexual problems Selective serotonin reuptake inhibitors (SSRIs) Citalopram (Celexa®) None Low Low/medium Low/medium Escitalopram (Lexapro®) None Low Low/medium Low/medium Fluoxetine (Prozac®, Prozac Weekly®, Sarafem®, Selfemra®) None Medium Low/medium Low/medium Fluvoxamine (only available as generic) Low Low Low/medium Low/medium Fluvoxamine CR (Luvox® CR) Low Low Low/medium Low/medium Paroxetine (Paxil®, Pexeva®) Low Low Low/medium Medium Paroxetine CR (Paxil CR®) Low Low Low Medium Sertraline (Zoloft®) None Low Medium Low/medium Dopamine-norepinephrine reuptake inhibitors Bupropion (Wellbutrin®) None Medium Low None Bupropion SR (Wellbutrin SR®, Budeprion SR®) None Low Low None Bupropion XL (Wellbutrin XL®, Budeprion XL®, Aplenzin™) None Low Low None Serotonin-norepinephrine reuptake inhibitors (SNRIs) Duloxetine (Cymbalta®) None Medium Medium Low/medium Venlafaxine (Effexor®) None Medium Low Low/medium Venlafaxine XR (Effexor XR®) None Medium Low Low/medium Serotonin modulators Nefazodone (only available as generic) Medium None Medium None Trazodone (Oleptro™) High None Low None Noradrenergic and specific serotonergic antidepressant Mirtazapine (Remeron®, Remeron SolTab®) High None None None * US brand names of medicines shown. Adapted from: Antidepressant Medicines - A guide for adults with depression. US Department of Health & Human Services. AHRQ publication number 07-EHC007-2A. 2007. Available at file://www.effectivehealthcare.ahrq.gov/ehc/products/7/10/AntidepressantsConsumerGuide.pdf .