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©2013 UpToDate ® Print Email Recommended antidotes in pediatric poisonings (continued) Antidote Poisoning indication Pediatric dose Ethanol (10 percent) Methanol Loading dose 10 mg/kg IV or PO, followed by maintenance dose 1 to 2 mL/kg per hour IV or PO Ethylene glycol Fomepizole (4-methylpyrazole) Methanol 15 mg IV bolus, then 10 mg/kg IV every 12 hours for four doses; after these, increase dose back to 15 mg/kg Ethylene glycol Glucagon Beta-adrenergic antagonist 0.15 mg/kg IV bolus followed by 0.1 mg/kg per hour IV infusion titrated to effect Calcium channel blocker Methylene blue Methemoglobinemia 1 to 2 mg/kg slow IV infusion, repeat doses are common Naloxone Acute opioid poisoning 0.4 to 2 mg IV, titrated to effect Pralidoxime chloride (PAM) Organophosphate insecticide 20 to 40 mg/kg slow IV infusion, followed by 5 to 10 mg/kg per hour continuous infusion or 20 mg/kg every four hours Pyridoxine Isoniazid (INH) 1 gm per gram ingested or empiric dosing 75 mg/kg IV bolus up to 5 g Sodium bicarbonate Tricyclic antidepressant 1 to 2 mEq/kg IV bolus, titrate repeat boluses to QRS duration do not exceed arterial pH 7.55) Cocaine Salicylates 150 mEq + 40 mEq KCl in 1L of D5W infused to maintain urine output at 1 to 2 mL/kg per hour and a urine pH approximately 7.5 Adapted from Dart, RC, Goldfrank, LR, Chyka, PA, Lotzer, D. Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann Emerg Med 2000; 36:126 and Clinical policy for the initial approach to patients presenting with acute toxic ingestion or dermal or inhalation exposure. Ann Emerg Med 1999; 33:735.