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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Anti-emetic drugs used to manage opioid-induced nausea Class Mechanism Examples Neuroleptics Dopamine receptor blockade in lower brainstem (chemoreceptor trigger zone) Phenothiazines: Prochlorperazine Chlorpromazine Butyrophenones: Haloperidol Atypical: Olanzepine Prokinetic drugs Peripheral effects to increase peristalsis; metaclopramide also has central dopamine antagonist Metoclopramide 5-HT3 receptor antagonists Block serotonin receptor (chronic use may cause constipation) Palonosetron Ondansetron Granisetron Dolasetron Anticholinergic drugs Block acetylcholine release in lower brainstem Trimethobenzamide Scopolamine Promethazine Antihistamines Block histamine receptors in lower brainstem Meclizine Diphenhydramine Dimenhydrinate Hydroxyzine Corticosteroids Multiple effects Dexamethasone Benzodiazepines Reduce anxiety; direct effect on lower brainstem Lorazepam Cannabinoids Binds to cannabinoid receptors to exert direct effect in the lower brainstem Dronabinol Nabilone