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contentuptodate· Content· item f5_10_5292

©2013 UpToDate ® Print Email Selection of antiemetics by clinical situation Situation Associated neurotransmitters Recommended antiemetic Migraine headache Dopamine (probably a primary mediator) For headache and nausea: metoclopramide (reglan) or prochlorperazine (compazine) For nausea: oral antiemetics, metoclopramide, prochlorperazine, serotonin antagonists Vestibular nausea Histamine, acetylcholine Antihistamines and anticholinergics (equally effective) Pregnancy-induced nausea Unknown For nausea: ginger, vitamin B6 For hyperemesis gravidarum: promethazine (phenergan, first-line agent); serotonin antagonists and corticosteroids (second-line agents) Gastroenteritis Dopamine, serotonin First-line agents: dopamine antagonists Second-line agents: serotonin antagonists Use in children is controversial Postoperative nausea and vomiting Dopamine, serotonin Prevention: serotonin antagonists, droperidol (inapsine), dexamethasone Treatment: dopamine antagonists, serotonin antagonists, dexamethasone Adapted from: Flake ZA, Scalley RD, Bailey AG. Practical selection of antiemetics. Am Fam Physician 2004; 69:1169.