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©2013 UpToDate ® Print Email Antihypertensive dose-response to thiazide therapy Antihypertensive response to bendrofluazide in relation to daily dose (in mg, multiply by 10 to get approximate equivalent doses of hydrochlorothiazide). The initial dose of 1.25 mg/day lowers the blood pressure in comparison to placebo; however, higher doses produced little further antihypertensive response. Each treatment group contained approximately 52 patients. Data from: Carlsen JE, Kober L, Torp-Pedersen C, Johannsen P. Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. BMJ 1990; 300:975.