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©2013 UpToDate ® Print Email Antimalarial drugs Drug Indication Cost* Available in the United States? Uncomplicated malaria Complicated malaria Prophylaxis Chloroquine X X $ Yes Amodiaquine X $ No Quinine X X $$ Yes (oral) Quinidine X $$$ Yes Mefloquine X X $$ Yes Halofantrine X $$ No Sulfadoxine-pyrimethamine X $ Yes Atovaquone-progunail X X $$$ Yes Artemether-lumefantrine X $$ Yes Clindamycin• X X $$ Yes Tetracycline, Doxycycline• X X X $ Yes PrimaquineΔ X (?) $ Yes * Cost based on lowest listed supplier prices for one complete adult treatment course (assumed weight 60 kg, where applicable), in 2007 US dollars: $ = less than one dollar; $$ = between one and ten dollars; $$$ = greater than ten dollars. • Given as part of combination therapy for treatment of malaria infection. Doxycline is used alone for prevention. Δ Administered in addition to acute treatment in cases of P. vivax or P. ovale for elimination of hypnozoite stage. Source: International Drug Price Indicator Guide; file://erc.msh.org/dmpguide/index.cfm?search_cat=yes&display=yes&module=dmp&language=English&year=2007).