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©2013 UpToDate ® Print Email Antimicrobial therapy for erysipelas For adults For children age >28 days* Oral therapy Penicillin 500 mg orally every 6 hours 25 to 50 mg/kg per day orally in 3 or 4 doses Amoxicillin 500 mg orally every 8 hours 25 to 50 mg/kg per day orally in 3 doses Erythromycin • 250 mg orally every 6 hours 30 to 50 mg/kg per day orally in 2 to 4 doses Parenteral therapy Ceftriaxone 1 g intravenously every 24 hours 50 to 75 mg/kg per day intravenously in 1 or 2 doses Cefazolin 1 to 2 g intravenously every 8 hours 100 mg/kg per day intravenously in 3 doses * Maximum single dose should not exceed dose for adults. • May not be adequate therapy in areas with relatively high resistance rates among beta-hemolytic streptococci.