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©2013 UpToDate ® Print Email Antineoplastic drugs that act as vesicants or irritants Vesicants Amsacrine Bendamustine* Carmustine Cisplatin (concentrations ≥0.5 mg/mL) Dactinomycin Daunorubicin Docetaxel (rare) Doxorubicin Epirubicin Idarubicin Liposomal vincristine Mechlorethamine Mitomycin Mitoxantrone (rare) Oxaliplatin (rare) Paclitaxel (rare) Trabectedin Vinblastine Vincristine Vindesine Vinorelbine Irritants Arsenic trioxide Bleomycin Bortezomib Busulfan Carboplatin Carmustine Cisplatin• Cladribine Cyclophosphamide Dacarbazine• Docetaxel Etoposide Fluorouracil/floxuridine Gemcitabine Ifosfamide Irinotecan Ixabepilone Liposomal daunorubicin• Liposomal doxorubicin• Melphalan Mitoxantrone• Oxaliplatin• Paclitaxel Streptozocin Teniposide Thiotepa Topotecan Trastuzumab emtansine * Although bendamustine is classified as a vesicant, postmarketing reports suggest that extravasation may lead to soft tissue injury. • May have vesicant properties, depending on the concentration of volume of drug extravasated. As an example, extravasation of large volume (>20 mL) of concentrated cisplatin (>0.5 mg/mL) may produce tissue necrosis.