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©2013 UpToDate ® Print Email Antithyroid drug comparisons Factor PTU Methimazole Response time Slower Faster Toxicity Dose-related hepatitis, vasculitis Dose-related, rare side-effects less common Compliance Worse Better Cost (monthly) $22 for 300 mg/day $62 for 30 mg/day; $21 for 10 mg/day Effect on radioiodine outcome Decreases effect Possible effect Adapted with permission from: Cooper DC. Antithyroid drugs in the management of patients with Graves' disease: An evidence-based approach to therapeutic controversies. J Clin Endocrinol Metab 2003; 88:3474. file://jcem.endojournals.org/. Copyright © 2003 The Endocrine Society.