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©2013 UpToDate ® Print Email Recommended daily dosage of influenza antiviral medications for treatment and prophylaxis of adults - United States Antiviral agent Dosage Zanamivir* • Treatment, influenza A and B 10 mg (2 inhalations) twice daily for five days Chemoprophylaxis, influenza A and B 10 mg (2 inhalations) once daily Δ Oseltamivir • Treatment, influenza A and B 75 mg twice daily for five days ◊ Chemoprophylaxis, influenza A and B 75 mg once daily Δ◊ * Zanamivir is administered through oral inhalation by using a plastic device included in the medication package. Patients will benefit from instruction and demonstration of the correct use of the device. Zanamivir is contraindicated in persons with asthma or chronic obstructive pulmonary disease. • Zanamivir should be used during outbreaks caused by oseltamivir-resistant influenza virus. It is important to assess the risk of oseltamivir-resistant influenza before choosing an antiviral drug for influenza prophylaxis. Clinicians should review local or state influenza surveillance data to determine which types of influenza (A or B) and subtypes (pandemic or seasonal H1N1; H3N2) of influenza A are circulating, as well as resistance patterns. This information, which is updated weekly, is available via the CDC through its website (www.cdc.gov/flu/weekly). Δ Duration of prophylaxis depends upon several factors. (See "Prevention of seasonal influenza in adults"). ◊ A reduction in the dose of oseltamivir is recommended for persons with creatinine clearance <30 mL/min. Adapted from: Influenza Division, National Center, for Immunization, and Respiratory. Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011; 60:1-28.