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contentuptodate· Content· item f7_46_7919

©2013 UpToDate ® Print Email Somatic rearrangements of the T cell receptor b chain germline DNA The B chain of the T cell antigen receptor is composed of variable (V), diversity (D), and joining (J) segments. Somatic rearrangements occur with D-J joining followed by V-D-J joining. The random addition and/or deletion of nucleotides (N) forming the NDbN account for the tremendous diversity of the variable region of the b chain. Adapted from T cell maturation in the thymus. In: Cellular and Molecular Immunology, Abbas, AK, Lithtman, AH, Pober, JS, (Eds), Philadelphia, WB Saunders 1994. p.172.