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©2013 UpToDate ® Print Email Arterial calcium stimulation with hepatic venous sampling for insulinoma Artery Time, seconds Serum hepatic vein insulin, µU/mL (pmol/L) Superior mesenteric 0 41 (284) 20 65 (451) 40 333 (2313) 60 441 (3063) Gastroduodenal 0 30 (208) 20 42 (292) 40 38 (264) 60 36 (250) Splenic 0 31 (215) 20 26 (180) 40 26 (180) 60 31 (215) Intraarterial injection of calcium, an insulin secretagogue in insulinoma patients but not normal subjects, and changes in hepatic venous serum insulin concentrations in a patient with suspected insulinoma. The hepatic venous serum insulin concentration increased 10-fold after superior mesenteric artery injection, 1.4-fold after the gastroduodenal artery injection, and did not change after the splenic artery injection. An insulinoma was removed from the uncinate process.