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©2013 UpToDate ® Print Email Determination of need for in-flight supplemental oxygen SpO 2 at rest breathing ambient air at sea level Further evaluation needed Supplemental oxygen needed in-flight >95 percent No No 92 to 95 percent without risk factors* No No 92 to 95 percent with risk factors* Yes• Depends on further evaluation <92 percent No Yes SpO 2 : oxygen saturation measured by pulse oximetry. * Risk factors include: Hypercapnia, forced expiratory volume in one second (FEV1) <50 percent of predicted, lung cancer, restrictive respiratory disease due to interstitial lung disease, chest wall abnormality, or respiratory muscle weakness, cerebrovascular or cardiac disease, exacerbation of chronic lung disease requiring hospitalization within the prior six weeks, pulmonary hypertension, previous dyspnea or chest pain during air travel, or inability to walk further than 50 m without distress. • Further evaluation includes use of a regression equation or hypoxia altitude simulation testing for prediction of in-flight arterial partial pressure of oxygen (PaO 2 ). See text for details.