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Patient information: Asthma symptoms and diagnosis in children (Beyond the Basics) Authors Gregory Sawicki, MD, MPH Kenan Haver, MD Section Editor Robert A Wood, MD Deputy Editor Elizabeth TePas, MD, MS Find Print ASTHMA OVERVIEW Asthma is a chronic condition with symptoms of cough, wheezing, chest tightness, and/or difficulty breathing. These symptoms occur periodically, usually related to specific triggering events. People with asthma have narrowed airways during these episodes; the narrowing is partially or completely reversible with asthma treatments. In addition, the airways of children with asthma react to a variety of stimuli, which may include viral illnesses (eg, the common cold), exercise, pollen, foods to which the child is allergic, or environmental conditions. Asthma is the most common chronic disease in children in developed countries, affecting about 12 percent of children who are less than 18 years. It is more common in males than females under the age of 15 years. This topic review discusses the risk factors, symptoms, and diagnosis of asthma in children. Other topics about asthma in children are available separately. (See "Patient information: Asthma treatment in children (Beyond the Basics)" and "Patient information: How to use a peak flow meter (Beyond the Basics)" and "Patient information: Asthma inhaler techniques in children (Beyond the Basics)" and "Patient information: Trigger avoidance in asthma (Beyond the Basics)" .) Discussions of asthma and asthma treatments in adults are also available. (See "Patient information: Asthma treatment in adolescents and adults (Beyond the Basics)" and "Patient information: How to use a peak flow meter (Beyond the Basics)" and "Patient information: Asthma inhaler techniques in adults (Beyond the Basics)" and "Patient information: Trigger avoidance in asthma (Beyond the Basics)" and "Patient information: Asthma and pregnancy (Beyond the Basics)" .) ASTHMA RISK FACTORS Asthma occurs when the small airways (bronchi) in the lungs become inflamed and narrowed, which limits the flow of air out of the lungs ( figure 1 and figure 2 ). This narrowing is almost always reversible in children with treatment. Many different genetic and environmental factors can increase the risk of developing asthma (see "Risk factors for asthma" ), a few of which include:

Asthma occurs when the small airways (bronchi) in the lungs become inflamed and narrowed, which limits the flow of air out of the lungs ( figure 1 and figure 2 ). This narrowing is almost always reversible in children with treatment. Many different genetic and environmental factors can increase the risk of developing asthma (see "Risk factors for asthma" ), a few of which include: Pollution — Increased exposure to indoor and outdoor pollution may increase the risk of developing asthma. Exposure to tobacco smoke — Exposure to tobacco smoke during pregnancy and throughout childhood increase the risk of developing asthma. Family history — Children with a personal or family history of certain medical problems, such as asthma, allergies, or eczema, are at increased risk of developing asthma. However, not all children with asthma have known risk factors. In other words, even children who live in rural areas and whose parents do not smoke or have asthma can develop asthma. It is not clear if there are ways to reduce a child's risk of developing asthma. ASTHMA SYMPTOMS Coughing and wheezing  — Symptoms of asthma in children include coughing and wheezing. The cough is usually dry and hacking and is most noticeable while the child sleeps and during early morning hours. It may also be triggered by exercise. Wheezing is a high-pitched musical noise that is usually heard when the child breathes out. It can generally only be heard with a stethoscope. Coughing and wheezing tends to come and go during the day or night, depending upon the degree of airway narrowing in the lungs. Breathlessness, chest tightness or pressure, and chest pain may also occur. In addition to coughing or wheezing, a child may report that their chest or stomach hurts. Asthma symptoms often develop in children before five years of age, although it is sometimes difficult to diagnose asthma in infants and toddlers. Asthma triggers  — Wheezing and coughing may occur at any time, but certain triggers are known to worsen asthma in many children.

Coughing and wheezing tends to come and go during the day or night, depending upon the degree of airway narrowing in the lungs. Breathlessness, chest tightness or pressure, and chest pain may also occur. In addition to coughing or wheezing, a child may report that their chest or stomach hurts. Asthma symptoms often develop in children before five years of age, although it is sometimes difficult to diagnose asthma in infants and toddlers. Asthma triggers  — Wheezing and coughing may occur at any time, but certain triggers are known to worsen asthma in many children. Environmental conditions  — In children with seasonal allergies, asthma symptoms may worsen during certain pollen seasons; trees pollinate in early spring, grasses in the late spring and summer, and weeds in the summer and fall. Symptoms can also flare as a result of mold growth (eg, during rainy seasons or in damp areas). Cold air, changes in barometric pressure, rain, or wind may cause increased asthma symptoms in certain people. Upper respiratory infections  — Viral upper respiratory infections (head and chest colds) are a common trigger of asthma in infants and young children. The most common viral infections include rhinovirus (the virus that causes most colds), respiratory syncytial virus, and influenza virus. (See "Patient information: The common cold in children (Beyond the Basics)" and "Patient information: Bronchiolitis (and RSV) in infants and children (Beyond the Basics)" .) Children with asthma should use their asthma treatments for cough and chest congestion rather than over-the-counter cold remedies. Exercise  — Narrowing of the airways can be triggered by exercise. This is called exercise-induced asthma (also called exercise-induced bronchoconstriction or EIB). Breathlessness, wheeze, and/or cough usually occur within 5 to 10 minutes of the cool-down period after vigorous exercise. These symptoms tend to disappear after 20 to 45 minutes. Certain types of exercise (eg, swimming) are less likely to cause exercise-induced asthma than others (eg, running, skating), probably because they produce less airway cooling and drying. Short bursts of activity tend to be better tolerated than prolonged exercise. (See "Patient information: Exercise-induced asthma (Beyond the Basics)" .)

Exercise  — Narrowing of the airways can be triggered by exercise. This is called exercise-induced asthma (also called exercise-induced bronchoconstriction or EIB). Breathlessness, wheeze, and/or cough usually occur within 5 to 10 minutes of the cool-down period after vigorous exercise. These symptoms tend to disappear after 20 to 45 minutes. Certain types of exercise (eg, swimming) are less likely to cause exercise-induced asthma than others (eg, running, skating), probably because they produce less airway cooling and drying. Short bursts of activity tend to be better tolerated than prolonged exercise. (See "Patient information: Exercise-induced asthma (Beyond the Basics)" .) Allergens and irritants  — Indoor and outdoor allergens are an important trigger of childhood asthma, particularly for children older than three years of age. Indoor pollutants can act as irritants and also trigger asthma symptoms. Irritants and allergens include: House dust (ie, dust mites, cockroaches, mice droppings), particularly during vacuuming Animal exposures; cats and dogs are especially provocative but other furry animals (gerbils, rabbits, hamsters, etc) may be suspect, particularly if symptoms only occur in settings where these animals reside Pollens Molds Indoor pollutants (eg, paint, perfume, cleaning products, space heaters, gas stoves, room deodorizers) If allergies are a possible cause of symptoms, skin or blood testing may be recommended. This can help to both identify triggers and determine the necessity of avoiding these triggers at home. Symptom patterns  — Children with chronic asthma may have one of several distinct patterns of symptoms: Intermittent asthma attacks with no symptoms between attacks Chronic symptoms with intermittent worsening Attacks that become more severe or frequent over time Morning "dipping", when symptoms worsen in the morning and improve as the day progresses Symptoms that begin during upper respiratory tract infections (eg, colds) and linger for several weeks after, with resolution during warmer weather. Most asthma attacks develop slowly over a period of several days. Uncommonly, a severe attack can occur suddenly and with minimal warning. ASTHMA DIAGNOSIS

Morning "dipping", when symptoms worsen in the morning and improve as the day progresses Symptoms that begin during upper respiratory tract infections (eg, colds) and linger for several weeks after, with resolution during warmer weather. Most asthma attacks develop slowly over a period of several days. Uncommonly, a severe attack can occur suddenly and with minimal warning. ASTHMA DIAGNOSIS The diagnosis of asthma in children requires a careful review of a child's current and past medical history, family history, and a physical examination. Specialized testing is sometimes needed to diagnose asthma and to rule out other possible causes of symptoms. Many children with asthma appear and sound completely normal. Spirometry testing  — The most accurate test for diagnosing asthma is spirometry or pulmonary function testing. Spirometry measures the flow and volume of air generated after a child takes a very deep breath and then forcefully tries to blow the air out of his/her lungs. If airflow obstruction is present, the test is repeated after the child uses an asthma inhaler (bronchodilator) to confirm that the obstruction is reversible (a feature of asthma). Children younger than six years sometimes have a hard time following the instructions to perform spirometry. Testing of younger children and infants is described below (see 'Testing for young children' below). Peak flow rate measurement  — Peak expiratory flow rate (PEFR) measurements require repeatable, maximal efforts to be accurate. The test requires that the child take a very deep breath and then quickly blow out as hard as possible into a device called a peak flow meter. This is generally done three times, with the highest value recorded as the result. PEFR measurements are occasionally used in the daily home monitoring of people with asthma. (See "Patient information: How to use a peak flow meter (Beyond the Basics)" .) Challenge testing  — If a child is thought to have asthma based upon the spirometry or PEFR result, a bronchial challenge may be recommended. This testing is designed to cause the airways to narrow in children with asthma. Testing is done in a specialized asthma testing center that is capable of providing emergency asthma care if needed. (See "Bronchoprovocation testing" .)

Challenge testing  — If a child is thought to have asthma based upon the spirometry or PEFR result, a bronchial challenge may be recommended. This testing is designed to cause the airways to narrow in children with asthma. Testing is done in a specialized asthma testing center that is capable of providing emergency asthma care if needed. (See "Bronchoprovocation testing" .) Additional testing  — Other tests may be recommended to ensure that another condition is not the cause of a child's coughing or wheezing. This may include a chest radiograph, sweat chloride test or blood test (for cystic fibrosis), barium swallow (for gastroesophageal reflux), modified barium swallow (for aspiration), or skin or blood testing (for allergies). (See "Wheezing illnesses other than asthma in children" and "Cystic fibrosis: Clinical manifestations and diagnosis" and "Clinical manifestations and diagnosis of gastroesophageal reflux disease in children and adolescents" and "Gastroesophageal reflux in infants" and "Aspiration due to swallowing dysfunction in infants and children" and "Overview of skin testing for allergic disease" and "Overview of in vitro allergy tests" .) Testing for young children  — Infants and children younger than six years are usually not able to perform spirometry or peak expiratory flow rate testing. In most cases, a healthcare provider will recommend a trial of medication to confirm the diagnosis. ASTHMA IN ADULTHOOD Many parents wonder if their child will "outgrow" their asthma over time. Children do experience complete remission more frequently than adults, although children with more severe asthma are more likely to continue to have asthma as adults. Having asthma does not typically affect the length of a person's life. However, a small percentage of people with asthma develop permanent changes in lung function that worsen over time. It is not known why this happens in some people and not in others. Factors that are believed to increase this risk include exposure to tobacco smoke, severe allergies, and severe and persistent asthma symptoms. ASTHMA TREATMENT The treatment of asthma in children is discussed in a separate topic review. (See "Patient information: Asthma treatment in children (Beyond the Basics)" .) WHERE TO GET MORE INFORMATION

Having asthma does not typically affect the length of a person's life. However, a small percentage of people with asthma develop permanent changes in lung function that worsen over time. It is not known why this happens in some people and not in others. Factors that are believed to increase this risk include exposure to tobacco smoke, severe allergies, and severe and persistent asthma symptoms. ASTHMA TREATMENT The treatment of asthma in children is discussed in a separate topic review. (See "Patient information: Asthma treatment in children (Beyond the Basics)" .) WHERE TO GET MORE INFORMATION Your child's healthcare provider is the best source of information for questions and concerns related to your child's medical problem. This article will be updated as needed on our web site ( www.uptodate.com/patients ). Related topics for patients, as well as selected articles written for healthcare professionals, are also available. Some of the most relevant are listed below. Patient level information  — UpToDate offers two types of patient education materials. The Basics  — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Patient information: Asthma in children (The Basics) Patient information: Cough in children (The Basics) Patient information: Secondhand smoke: Risks to children (The Basics) Patient information: Bronchiectasis in children (The Basics) Beyond the Basics  — Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are best for patients who want in-depth information and are comfortable with some medical jargon.

Patient information: Asthma in children (The Basics) Patient information: Cough in children (The Basics) Patient information: Secondhand smoke: Risks to children (The Basics) Patient information: Bronchiectasis in children (The Basics) Beyond the Basics  — Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are best for patients who want in-depth information and are comfortable with some medical jargon. Patient information: Asthma treatment in children (Beyond the Basics) Patient information: How to use a peak flow meter (Beyond the Basics) Patient information: Asthma inhaler techniques in children (Beyond the Basics) Patient information: Trigger avoidance in asthma (Beyond the Basics) Patient information: Asthma treatment in adolescents and adults (Beyond the Basics) Patient information: Asthma inhaler techniques in adults (Beyond the Basics) Patient information: Asthma and pregnancy (Beyond the Basics) Patient information: The common cold in children (Beyond the Basics) Patient information: Bronchiolitis (and RSV) in infants and children (Beyond the Basics) Patient information: Exercise-induced asthma (Beyond the Basics) Professional level information  — Professional level articles are designed to keep doctors and other health professionals up-to-date on the latest medical findings. These articles are thorough, long, and complex, and they contain multiple references to the research on which they are based. Professional level articles are best for people who are comfortable with a lot of medical terminology and who want to read the same materials their doctors are reading.

Professional level information  — Professional level articles are designed to keep doctors and other health professionals up-to-date on the latest medical findings. These articles are thorough, long, and complex, and they contain multiple references to the research on which they are based. Professional level articles are best for people who are comfortable with a lot of medical terminology and who want to read the same materials their doctors are reading. Acute asthma exacerbations in children: Inpatient management Acute asthma exacerbations in children: Outpatient management Acute severe asthma exacerbations in children: Intensive care unit management An overview of asthma management Anticholinergic agents in the management of acute exacerbations of asthma Approach to wheezing in children Chronic asthma in children younger than 12 years: Controller medications Chronic asthma in children younger than 12 years: Definition, epidemiology, and pathophysiology Chronic asthma in children younger than 12 years: Evaluation and diagnosis Chronic asthma in children younger than 12 years: Quick-relief agents Exercise-induced bronchoconstriction Natural history of asthma Risk factors for asthma The impact of breastfeeding on the development of allergic disease Wheezing illnesses other than asthma in children The following organizations also provide reliable health information. National Library of Medicine ( www.nlm.nih.gov/medlineplus/healthtopics.html ) National Heart, Lung, and Blood Institute ( www.nhlbi.nih.gov/ ) American Lung Association ( www.lungusa.org ) American Academy of Allergy, Asthma, and Immunology ( www.aaaai.org/patients.stm ) American College of Allergy, Asthma, and Immunology ( www.acaai.org/allergist ) Allergy and Asthma Network/Mothers of Asthmatics, Inc. ( www.aanma.org/ ) [ 1-5 ] Literature review current through: Oct 2013. | This topic last updated: Dec 12, 2011. Find Print The content on the UpToDate website is not intended nor recommended as a substitutefor medical advice, diagnosis, or treatment. Always seek the advice of your own physician orother qualified health care professional regarding any medical questions or conditions. Theuse of this website is governed by the UpToDate Terms of Use ©2013 UpToDate, Inc. References Top Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol 2007; 42:723.

The content on the UpToDate website is not intended nor recommended as a substitutefor medical advice, diagnosis, or treatment. Always seek the advice of your own physician orother qualified health care professional regarding any medical questions or conditions. Theuse of this website is governed by the UpToDate Terms of Use ©2013 UpToDate, Inc. References Top Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol 2007; 42:723. Gruchalla RS, Pongracic J, Plaut M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol 2005; 115:478. Porsbjerg C, von Linstow ML, Ulrik CS, et al. Risk factors for onset of asthma: a 12-year prospective follow-up study. Chest 2006; 129:309. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003; 349:1414. McFadden ER Jr. Natural history of chronic asthma and its long-term effects on pulmonary function. J Allergy Clin Immunol 2000; 105:S535.