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Note: Attapulgite preparations have been discontinued in the U.S.; refer to Bismuth monograph for newly-reformulated Kaopectate® products. Contraindications Hypersensitivity to attapulgite or any component Warnings Not to be used for self-medication for diarrhea >48 hours or in the presence of high fever in infants and children <3 years of age; do not use for diarrhea associated with pseudomembranous enterocolitis or in diarrhea caused by toxigenic bacteria Metabolism/Transport Effects None known. Drug Interactions (For additional information: Launch Lexi-Interact™ Drug Interactions Program ) There are no known significant interactions. Mechanism of Action Controls diarrhea because of its absorbent action Patient Information Do not exceed maximum number of doses per day; drink plenty of fluids; contact your physician if diarrhea persists more than 48 hours or if fever develops in children <3 years of age Additional Information Kaopectate®, Kaopectate® Advanced Formula, Children's Kaopectate®, and Kaopectate® Maximum Strength have been reformulated. Previously, Kaopectate® contained attapulgite. The new formulation contains only bismuth subsalicylate. Bismuth salicylate has significant contraindications, particularly in children with influenza and chickenpox. Please refer to bismuth monograph for product information. During the transition period, the older formulation may still be available, read product label closely. Use of UpToDate is subject to the Subscription and License Agreement . Topic 12891 Version 31.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.6- C21.56 Licensed to: AsanBook Dig. Med. Lib. | Support Tag: [1004-122.72.76.133-3453397B85-S244013.14]