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©2013 UpToDate ® Print Email Atypical antidepressants: Doses for treating unipolar major depression Drug Usual starting dose (mg per day) Usual daily dose (mg) Extreme daily dose (mg)* Agomelatine 25 25 to 50 25 to 50 Bupropion Immediate release • 200 300 100 to 450 Sustained release Δ 150 300 150 to 400 Extended release ◊ 150 300 150 to 450 Mirtazapine 15 15 to 45 7.5 to 60 * Lower doses are often used for elderly, medically compromised (eg, renal or liver disease), or drug sensitive patients, as well as patients with a lower body mass index. Higher doses may be used for medications that are well tolerated but ineffective at lower doses. • Maximum single dose: 150 mg per day. Δ Maximum single dose: 200 mg per day. ◊ Maximum single dose: 300 mg per day in Europe; 450 mg per day in the United States. Data from: Gartlehner G, Thaler K, Hill S, Hansen RA. How should primary care doctors select which antidepressants to administer? Curr Psychiatry Rep 2012; 14:360. Labbate LA, Fava M, Rosenbaum JF, Arana GW. Drugs for the treatment of depression. In: Handbook of Psychiatric Drug Therapy, 6th Ed, Lippincott Williams and Wilkins, Philadelphia 2010, p.54.