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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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Adverse Reactions Central nervous system: Fatigue, headache Dermatologic: Pruritus Gastrointestinal: Bitter taste Ocular: Blurred vision (temporary), conjunctivitis, eye pain, transient burning/stinging Respiratory: Asthma, dyspnea, pharyngitis, rhinitis Miscellaneous: Flu-like syndrome Contraindications Hypersensitivity to azelastine or any component Warnings Ophthalmic solution not for use in contact lens-related irritation; preservative in ophthalmic solution may be absorbed by soft contact lenses; wait at least 10 minutes after instillation before inserting soft contact lenses Metabolism/Transport Effects None known. Drug Interactions (For additional information: Launch Lexi-Interact™ Drug Interactions Program ) There are no known significant interactions. Pregnancy Risk Factor C ( show table ) Pregnancy Implications Animal reproduction studies have shown toxic effects to the fetus at maternally toxic doses. Mechanism of Action Competes with histamine for H 1 -receptor sites on effector cells in the blood vessels Patient Information (For additional information see "Azelastine (ophthalmic): Patient drug information" ) May cause drowsiness and impair ability to perform activities requiring mental alertness or physical coordination. Use of UpToDate is subject to the Subscription and License Agreement . Topic 15941 Version 21.0 © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement | Release: 21.4 - C21.36 Licensed to: Southeast Alabama Med Ctr | Support Tag: [0604-115.66.252.144-403C6C9E42-S244013.14]