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©2013 UpToDate ® Print Email Peripheral blood morphology of four different B cell leukemias (A) B-cell prolymphocytic leukemia, showing monomorphic prolymphocytes with condensed chromatin, prominent nucleolus, and scanty basophilic cytoplasm. (B) Chronic lymphocytic leukemia with increased prolymphocytes, showing a single prolymphocyte, and several typical CLL cells, which are half the size of the prolymphocyte, have less cytoplasm and no nucleolus. (C) Variant form of hairy cell leukemia, showing cells with condensed chromatin and a conspicuous single nucleolus, but with more abundant pale cytoplasm with cytoplasmic projections. (D) Splenic marginal zone lymphoma showing lymphocytes with short polar villi and basophilic cytoplasm. This research was originally published in Blood. Dearden C. How I treat prolymphocytic leukemia. Blood 2012; 120:538. Copyright © 2012 American Society of Hematology.