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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Characteristics of B cell subsets B-1a B-1b B-2, "Conventional" CD5 Constitutive Inducible Inducible CD11b/CD18 Yes Yes No CD45RA Low Low High Immunoglobulins Low-affinity High-affinity High-affinity Polyreactive Specific Specific Germline VH, VL Mutated VH, VL Mutated VH, VL IgM IgG, IgA, IgE IgG, IgA, IgE Origin Self-replenishing Bone marrow Bone marrow Location Blood Blood Blood Peritoneal cavity Follicular mantle Follicular mantle CD5 ligation Induce TNF and IL-2R Apoptosis Apoptosis VH: heavy chain variable region genes; VL: light chain variable region genes; TNF: tumor necrosis factor; IL-2R: interleukin-2 receptor. CD45A is the high molecular weight form of CD45 (leukocyte common antigen). Data from Youinou, P, Jamin, C, Lydyard, PM. Immunol Today 1999; 20:312. (page 314, table2).