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©2013 UpToDate ® Print Email Recommendations for postexposure prophylaxis for persons exposed to B virus Prophylaxis recommended Skin exposure* (with loss of skin integrity) or mucosal exposure (with or without injury) to a high-risk source (eg, a macaque that is ill, immunocompromised, or known to be shedding virus or that has lesions compatible with B virus disease) Inadequately cleaned skin exposure (with loss of skin integrity) or mucosal exposure (with or without injury) Laceration of the head, neck, or torso Deep puncture bite Needlestick associated with tissue or fluid from the nervous system, lesions suspicious for B virus, eyelids, or mucosa Puncture or laceration after exposure to objects (a) contaminated either with fluid from monkey oral or genital lesions or with nervous system tissues, or (b) known to contain B virus A postcleansing culture is positive for B virus Prophylaxis considered Mucosal splash that has been adequately cleaned Laceration (with loss of skin integrity) that has been adequately cleaned Needlestick involving blood from an ill or immunocompromised macaque Puncture or laceration occurring after exposure to (a) objects contaminated with body fluid (other than that from a lesion), or (b) potentially infected cell culture Prophylaxis not recommended Skin exposure in which the skin remains intact Exposure associated with nonmacaque species of nonhuman primates * Exposures include macaque bites; macaque scratches; or contact with ocular, oral, or genital secretions, nervous system tissue, or material contaminated by macaques (eg, cages or equipment). Reproduced with permission from: Cohen, JI, Davenport, DS, Stewart, JA, et al. Recommendations for Prevention of and Therapy for Exposure to B Virus (Cercopithecine Herpesvirus 1). Clin Infect Dis 2002; 35:1191. Copyright © 2002 University of Chicago Press.